Manchester City are adjusting to a significant blow against their Premier League title defence after confirmation Kevin De Bruyne will be sidelined for around three months with lateral knee ligament damage.
The Belgium midfielder, who was City's stand-out performer on the way to Premier League and EFL Cup glory last season, suffered the injury during a training session this week.
Pep Guardiola has an amply stocked squad from which to find solutions to this conundrum, although there is arguably no like-for-like replacement for De Bruyne's all-round midfield mastery.
Here we look at what fixtures City will have to tackle without their talisman and which rivals at home and abroad might be set to benefit from his absence.
Generous early season run
City already have the scalp of a top-six counterpart in the Premier League this term having breezed past Arsenal 2-0 on the opening weekend. The immediate run of fixtures to come appear straightforward on paper and take out a sizeable chunk of De Bruyne's absence.
Starting with Sunday's home game against Huddersfield Town, Guardiola's men face the promoted sides from this season and last season over a six-match period. Complacency should be guarded against, however. Huddersfield were one of only three teams to avoid defeat at the Etihad Stadium in the Premier League in 2017-18, while City needed penalties to overcome Wolves in the EFL Cup.
Champions League group stage
Whoever City face in the round-robin phase of Europe's elite club competition, each opponent will be buoyed by the prospect of not having to tackle De Bruyne. Game-changing goals against Sevilla, Paris Saint-Germain, Barcelona and Shakhtar Donetsk feature among his body of work in a tournament his employers are yet to tame.
City have won 58.3 per cent of their Champions League games with De Bruyne since he joined from Wolfsburg in 2015. That figure drops to 16.7 per cent – one out of six – in the games he has missed. Guardiola must mastermind an improvement, with the first four group-stage matchdays now out of bounds.
A daunting Anfield task
Even with De Bruyne at their disposal, City generally struggled against Liverpool last season. After a 5-0 romp in the wake of a Sadio Mane red card at the Etihad, the champions lost the subsequent three encounters in the Premier League and a Champions League quarter-final.
This included 4-3 and 3-0 reverses at Anfield, where City have not won since 2003. Jurgen Klopp's side have been tipped by many to present the sternest test to Guardiola's ambition of becoming the first manager to retain England's top-flight crown since Alex Ferguson. The Catalan would have dearly loved to have De Bruyne around for a high-stakes showdown on October 7.
KDB— Benjamin Mendy (@benmendy23) August 17, 2018
Tottenham away (probably)
The second international break of De Bruyne's scheduled absence – a factor in City's favour – comes after the Liverpool game. They return at home to Burnley before taking on Tottenham. Mauricio Pochettino took four points off Guardiola during the latter's first season in England but City stormed to two impressive wins in 2017-18. De Bruyne scored a stunning solo goal in a 4-1 victory last December.
A trip to a top-four rival remains a significant moment in any title bid, although the October 28 clash is cloaked in uncertainty as Tottenham race to get their new stadium ready. The venue is presently listed as TBC on Spurs' website, with NFL taking place at their temporary home of Wembley on October 27.
Manchester derby return
Injury struck for De Bruyne on August 15 and the timeframe outlined by City for his recovery means attention is quickly drawn to the first Manchester derby of the season on November 11. City v United; Guardiola v Mourinho – it would be the perfect time to reintroduce the playmaker's star quality.
|Lindelof rues international break for Man Utd|
|Shaqiri confident in more goals for Liverpool|
|Giants too good for 49ers in crunch time|
|Southgate named honorary Yorkshireman|
|Nicky Butt: Manchester United low on confidence|
|Sissoko: Dembele criticism overblown|
|Thibodeau discusses Butler trade: We thought this was the best deal for us|
|Acuna, Ohtani win rookie of the year awards|
|LeBron James on Lakers’ early season struggles: ‘I almost cracked’|
|Welbeck has successful second operation on broken ankle|
|UEFA warns FFP cases can be reopened based on ´new information´|
|Foakes to keep England place for second Test|
|WATCH: Rooney looking sharp in England training return|
|Mbappe: Money in football is truly indecent|
|Djokovic back to brilliant best as Isner is beaten|
|Celta Vigo replace Mohamed with Cardoso after Real Madrid defeat|
|Joshua intrigued by Usyk, says Hearn|
|Ibrahimovic beats Rooney to MLS Newcomer award|
|Rams WR Kupp out for season with torn ACL|
|Sturridge denies ever gambling on football following FA charge|
|Koeman understands De Ligt´s Eredivisie frustrations|
|Jimmy Butler trade: 76ers acquire Timberwolves star in blockbuster deal|
|´Improve your attitude´ - Deschamps issues Dembele warning|
|Sturridge charged with misconduct over alleged breach of betting rules|
|Saints sign Marshall following Bryant injury|
|Mendy suffers knee injury, leaves France squad with Lacazette|
|Zverev beats Cilic in error-strewn London battle|
|Rafinha replaces injured Casemiro in Brazil squad|
|´One-dimensional´ Australia batsmen need work before World Cup - Finch|
|Mancini keen to work with ´incredibly gifted´ Tonali|
|Italian manager of the year Allegri targets long Juve stay|
|Injured Lee departs as Wales prepare squad for Tonga|
|Conte content to wait until June for coaching return|
|Etzebeth set to return, Whiteley a doubt for Scotland Test|
|In-form Verstappen does not need distractions from 2019 challenge|
|FA asks Guardiola to explain Manchester derby referee comments|
|LaLiga MVP Messi hopes the division stays wide open|
|Murray and Henshaw out of All Blacks Test|
|Injured Man Utd duo Pogba and Martial drop out of France squad|
|Modric cannot always be the best - Dalic|
|Very troubling times - LeBron James alarmed by gun violence|
|Bayern confirm Ribery ´altercation´ with reporter|
|Madrid hit by injuries to Nacho and Casemiro|
|Record-breaking Mushfiqur torments Zimbabwe|
|Spartak Moscow appoint Oleg Kononov|
|Rooney predicts ´exciting time´ after being named in MLS Best XI|
|Former England call-up Graham replaces Thomson in Scotland squad|
|Slater and Thurston among Queensland greats to join Maroons staff|
|Rapana set for six months out after shoulder surgery|
|Alves determined to play in the Premier League|
|Rockets GM denies Anthony will be waived|
|Monaco´s plight not Henry´s fault - Silva|
|It´s like the FBI came - River assistant unable to talk to Gallardo during final|
|Norman says Washington home crowds ´just don´t really care´|
|Bucks beat Nuggets to finish gruelling schedule stretch|
|Madrid ´very happy´ with Solari, says Butragueno|
|Titans stun Patriots, Browns upset Falcons|
|Browns´ Chubb relishes record-breaking performance: It definitely is very special|
|MLS Review: Red Bulls, Atlanta to meet in conference finals|
|Neymar wants more from perfect PSG|
|Higuain is feeling a lot of pressure – Gattuso|
|I didn´t insult anyone, says apologetic Higuain|
|Allegri delighted with Juventus response|
|Kyle Busch wins at Phoenix as Harvick, Truex qualify for Championship 4|
|WATCH: Highlights of thrilling Boca-River Copa Libertadores final|
|PSG coach Tuchel demands more despite Monaco thrashing|
|Boca missed too many chances, rues Schelotto|
|Solari remains tight-lipped on Real Madrid future|
|Hamilton not surprised by Verstappen-Ocon collision|
|Ronaldo fires Juventus to Serie A record|