It was a bad day for seeds as Jack Sock, John Isner and Milos Raonic all lost in the second round of the Delray Beach Open.
Sock, Isner and Raonic were the only seeds in action on Wednesday and the trio surprisingly crashed out, denied spots in the quarter-finals.
Top seed and defending champion Sock was the biggest casualty, upstaged by wildcard and fellow American Reilly Opelka 4-6 7-5 6-3 at the ATP 250 tournament.
Sock has endured a disappointing start to the season, with his only win of the year coming at this event, having lost in Auckland and the first round of the Australian Open.
And the world number eight's woes continued, despite claiming the opening set against his unfancied opponent.
Opelka will face Peter Gojowczyk in the quarters after the German eliminated sixth seed Isner.
With only two wins to his name this year, three-time Delray Beach semi-finalist Isner fell to another disappointing defeat, beaten 7-6 (7-3) 6-7 (4-7) 7-6 (7-5).
Gojowczyk will contest his third quarter-final of the year, having already reached the last eight in Doha and Auckland.
Last year's runner-up Raonic was also sent packing following his 6-2 6-4 loss to Steve Johnson.
Raonic – the Canadian ninth seed – tasted defeat against Johnson for the first time in his career as he fell to a 1-3 record for the year.
"I've got to definitely review it, think about it, because that was a pretty poor level I put out there today. Not much to be happy with," he said.
"I think he was just sharp. I've played him before so I knew what to expect. He was more aggressive today than other times. Was that my lack of creation, or was he just taking over and making me feel, in a lot of ways, silly out there? I had a tough time with a lot of things today."
Johnson will face Evgeny Donskoy, who overcame Donald Young 7-6 (8-6) 6-3.
|Reds rally to complete four-game sweep of Cubs|
|Arzani ready for Socceroos start against Peru – Skoko|
|Braves place closer Vizcaino on DL with right shoulder inflammation|
|West Indies hold slight edge against Sri Lanka|
|Don´t touch my Grizou – Pogba defends France team-mate|
|Yankees catcher Sanchez likely heading to DL|
|Messi is frustrated and hungry – Mascherano|
|Nainggolan the ´ninja´ Inter were missing, says Spalletti|
|Anthony fires back at Thunder fans unhappy he´s staying|
|MLS Review: New York City edge Toronto in Torrent´s first game|
|Watson shoots 63 to win Travelers for third victory of season|
|Iran contest not all about Ronaldo, insists Santos|
|Truex´s team use tricky strategy to win at Sonoma|
|World Cup 2018: England at home, Brazil´s party and exploding White Nights in St Petersburg|
|Pogba reveals ´issues´ with Mourinho|
|Mascherano plays down rumours of Sampaoli bust-up|
|Sweden winger Durmaz says racist abuse ´passed limit´|
|Morgan hails ´outstanding´ Buttler century|
|Paine to discuss ODI future after England whitewash|
|Cuper unsure of Egypt future as El Hadary nears milestone|
|Koepka ´shutting down´ until Carnoustie|
|Quintero and James plot Colombia´s way through uncharted territory|
|Federer upbeat despite shock Halle defeat|
|Journalists should round on Vettel - Verrstappen|
|Poland 0 Colombia 3: Falcao´s maiden World Cup goal revitalises Pekerman´s side|
|World Cup 2018: Cossack kids, Swan Lake and the Selecao in Rostov-on-Don|
|Maria takes maiden title in Mallorca|
|Hierro: I am 100 per cent the coach of Spain|
|Busquets recognises Iniesta´s burning ambition|
|Denmark v France: Tolisso hoping for second chance|
|Eight-try Wakefield hammer sorry Widnes|
|World Cup 2018: A panda, a tapir and a nightmare for Willy in Nizhny|
|Senegal´s Wague makes African history in World Cup|
|Cilic fights back to beat Djokovic in enthralling Queen´s final|
|Neymar and Suarez among players to send Messi birthday wishes|
|Strength of Senegal and Japan´s determination could trouble England and Belgium|
|Hamilton questions Vettel punishment after Bottas´ race ´destroyed´|
|Brilliant Buttler seals whitewash in Old Trafford thriller|
|World Cup 2018: An egg-and-spoon race, vodka and the Pogbas in Kazan|
|Queiroz tells his Iran players to follow the ´three Rs´ against Ronaldo and Portugal|
|Pizzi calm over Salah threat|
|Japan 2 Senegal 2: Honda gatecrashes Cisse´s party|
|Harden should be MVP ´hands down´, says World Peace|
|Southgate optimistic over Alli recovery for Belgium decider|
|Neymar´s tears no surprise to Fagner|
|Unhappy Renard continues ref rant|
|Wallace takes BMW International title despite Olesen 61|
|Hamilton cruises back to standings summit with France win|
|In-form Kvitova defends Birmingham title|
|Southgate responds to toughest England week in record-breaking style|
|Uruguay not thinking about Portugal or Spain, insists Cavani|
|Coric stuns Federer to claim title in Halle|
|England 6 Panama 1: Kane hat-trick sees Southgate´s side sail through|
|Australia v Peru: Juric keeping the faith as Socceroos chase unlikely last-16 spot|
|England surpass class of 1966 in Panama rout|
|Nigeria v Argentina: All eyes on Messi to rescue final World Cup chance|
|NSW seal Origin series with comeback win|
|World Cup 2018: Stalin´s bunker, a space museum and Serbian specials in Samara|
|Croatia looking out for number one - Lovren|
|Heritage at back of Australian minds ahead of potential Croatia encounter|
|It may be my last World Cup - ´Realistic´ Pogba determined to reign in Russia|
|Lionel Messi´s birthday: What might the Barcelona star wish for?|
|Russia readying Dzagoev for last-16 clash|
|Germany apologised for reaction aimed at Sweden bench|
|Picture this! Sterling starts for England against Panama|
|World Cup 2018: A Russian romp, Maradona and the party in Moscow|
|Happy birthday, Lionel Messi! 10 of the Argentina star´s best goals|
|Modric worthy of Ballon d´Or, says Lovren|
|Sigurdsson ready for Croatia reunion as Iceland go for broke|
|Iceland v Croatia: Dalic to rest stars for Hallgrimsson divorce hearing|